The Impact of Cerium Oxide Nanoparticles on Reactive Oxygen Species (ROS) Release Rate in Mice Organs
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Abstract
The impact of exposing significant mouse organs to cerium oxide nanoparticles (CeO2 NPs) has received considerable attention in the literature, but a comprehensive review on this topic is lacking. This review aims to address this gap by examining the influence of CeO2 NPs on the release rate of reactive oxygen species (ROS) in various organs of mice. CeO2 NPs have demonstrated potential therapeutic applications due to their ROS-scavenging abilities, which are relevant to oxidative stress-related diseases. Recent studies investigating the effect of CeO2 NPs on ROS release rate in organs such as the liver, spleen, lung, and brain are highlighted in this article. The findings reveal a complex interaction between CeO2 NPs and the ROS system, influenced by factors such as particle dose, size, and surface chemistry. Furthermore, the impact of CeO2 NPs on ROS release rate is organ-specific and dependent on the tissue microenvironment. The review also addresses the potential toxicity of CeO2 NPs and emphasizes the need for further research to better comprehend their mechanisms of action and long-term effects. By providing valuable insights into the influence of CeO2 NPs on ROS release rate in mice organs, this review holds significant implications for the therapeutic applications of CeO2 NPs in oxidative stress-related diseases. This review contributes to the existing body of knowledge by examining the impact of CeO2 NPs on ROS release rate in various mouse organs
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